Lewes, DE -- (SBWire) -- 10/13/2015 --Despite few products having so far reached the market and captured strong revenues, the gene therapies pipeline remains large, with 906 products in active development across all stages. However, the majority of these remain in early steps of development, with 76% at either the Discovery or Preclinical stage, according to new report.
The company's latest report states that oncology, infectious diseases, genetic disorders, cardiovascular diseases and ophthalmological indications are the most active pipeline sectors, as well as the most widely studied in terms of the number of clinical trials.
There are 266 pipeline gene therapies in active development for oncology, more than double that of central nervous system disorders, which is the second-largest therapy area. Furthermore, oncology also accounted for 64% of gene therapies clinical trials between 1989 and 2012.
According to Senior Analyst for Publisher, says: "Oncology is the predominant area for gene therapies developments due to its high prevalence and genetically driven pathophysiology.
"One reason for the large overall pipeline is the potential for these therapies to develop strong drugs by targeting diseases on a genetic level. Although no products have yet fulfilled this promise, developers expect this in the future."
The report also states that, based on pipeline activity, Isis Pharmaceuticals is a major player in the gene therapies research and development space, with 31 gene silencing-based programs in development across the key therapy areas. Sarepta and Alnylam Pharmaceuticals are also key players, with 25 and 24 pipeline products in development, respectively.
Senior Analyst explains: "In the next decade, these late-stage pipeline developments may translate into clinically and commercially successful gene therapies entering the market. However, high pipeline failure rates due to challenges in developing safe and efficient delivery vectors will remain a barrier.
"Other potential obstacles to gene therapies development include difficulties in manufacturing and purifying viral vectors, as well as increased regulatory oversight by the US Food and Drug Administration and general caution from worldwide regulatory bodies following previous trial deaths," concludes the analyst.
Gene therapies: A Diverse Range of Technologies with a Promising Long-Term Outlook report provides analysis of the gene therapies product pipeline, including details on the relative clinical and commercial success of currently marketed products and the current competitive landscape, with a detailed breakdown of companies actively involved in the gene therapies pipeline.
This report was built using data and information sourced from proprietary databases, primary and secondary research, and in-house analysis conducted by Publisher's team of industry experts.
For more information on this report, please visit- http://www.marketresearchreports.com/cbr-pharma-insights/gene-therapies-diverse-range-technologies-promising-long-term-outlook
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