Lewes, DE -- (SBWIRE) -- 11/21/2016 -- This report describes and evaluates the competitive landscape of CD22-targeted immunotherapeutics based on different treatment modalities. In B-cell non-Hodkgina lymphoma (NHL), CD22 expression ranges from 91% to 99% in the aggressive and indolent populations, respectively. CD22 expression occurs in more than 90% of patients with B-lineage acute lymphoblastic leukemia (ALL). CD22 is not expressed on non-B lineage cells or hematopoietic stem cells. In addition, CD22 is rapidly internalized after binding of the anti-CD22 antibody and is not shed in the extracellular environment, features that make it an attractive antigen for targeted delivery of payloads by immunotherapeutics such as antibodies or engineered T-cells.

Monotherapy of NHL and ALL with naked anti-CD22 antibodies only achieved modest efficacy results indicating the need for more effective payloads, but at the same time also providing development opportunities for new treatment modalities such as
- Combination therapies;
- Radioimmunotherapy (RIT);
- Immunotoxins (IT);
- Antibody-Dug Conjugates (ADC); and
- Chimeric Antigen Receptor (CAR) T-Cells.

This report describes the profiles of 16 different specific and bispecifi anti-CD22 immunotherapeutics based on different treatment modalities. The most advanced molecules has been submitted for regulatory approval. Furthermore, the profiles of nine companies active in the development of anti-CD22 immunotherapeutics are presented.

This report describes and analyzes the
- Target Background & Scientific Rationale
- Clinical Proof-of-Concept of CD22-Targeted Immunotherapeutics
- Competitive Landscape
- Profiles of Anti-CD22 Immunotherapeutics
- Profiles of Companies with CD22-Targeted Immunotherapeutics

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