Endpoints - Clinical Trials in Autoimmune Disorders - Multiple Primary and Secondary Endpoints Are Increasingly Being Applied to Ensure Success
Major marketed drugs for RA are Enbrel (etanercept), Humira (adalimumab), Remicade (infliximab), Rituxan (rituximab), and Celebrex (celecoxib). With a sales figure of more than one billion, all five drugs are considered to be blockbusters. The endpoints used in their clinical trials are American College of Rheumatology (ACR) criteria. ACR response criteria consist of clinical symptoms and signs of inflammation including fatigue, joint pain, morning stiffness, joint tenderness, joint swelling, and Erythrocyte Sedimentation Rate (ESR). This is a used as a...
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