Paroxysmal Nocturnal Hemoglobinuria (PNH) – Improved Therapies Are About to Launch
Paroxysmal Nocturnal Hemoglobinuria (PNH) is an acquired genetic disorder caused by a mutation in X chromosome gene PIGA (Phosphatidylinositol glycan class A), leading to the destruction of red blood cells, and subsequent release of hemoglobin into plasma. There are mainly three types of PNH cells, namely Normal (type I) stem cells, PNH (type II) stem cell, and PNH (type III) stem cells. Approximately one-half of the patients with PNH die from the disease within 10 years of diagnosis. It occurs...
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