Seattle, WA -- (SBWIRE) -- 10/02/2019 -- Stem cell and bone marrow transplants may often lead to mild or severe some complications. These complications can be referred as graft versus host disease (Gvhd) and occur especially in immune-compromised patients. The radioactive agents or chemicals used during cancer treatment can have adverse impact on healthy cells, which may lead to reconstruction of the body cells. Stem cell and bone marrow transplant can be used to fix this reconstruction. A patient receives the bone marrow from a donor through infusion following a high dose of chemotherapy. The approach aids in resuming the production of blood cells. Gvhd occurs when a particular type of white blood cells is not compatible with the existing cell type. In Gvhd, the transplanted cells attack the recipient body. It is challenging to diagnose the agents and the compatibility during the transplant. Although Gvhd is not associated with severe symptoms, the condition can be fatal. A patient is free from such complications during autologous transplant. Cells of the donor and recipient are required to be thoroughly screened and matched before the transplant in order to eliminate the risk of acquiring Gvhd.

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Graft Versus Host Disease Market Taxonomy:

By Disease Type -

- Acute graft vs. host disease (aGvHD)
- Chronic graft vs. host disease (cGvHD)

By Product Type -

- Monoclonal antibodies
- mTOR inhibitors
- Tyrosine kinase inhibitors
- Thalidomide
- Etanercept

Increasing R&D related to Gvhd is expected to boost growth of the market:

Increasing development of biological and patented small molecule immunosuppressive therapies such as Adienne Pharma's Begedina and mesenchymal stem cell therapies has significantly contributed to growth of the market. Some of the emerging trends in R&D in Gvhd include maintaining appropriate prophylactic regimens and inhibiting proliferation and activation of T-cell, which are tailored to conditioning and transplant type and used for hematopoietic stem cell transplantation (HSCT). However, the process can lead to infection.

Key research institutes are focused on R&D and conducting clinical studies for targeting niche subgroup under Gvhd such as steroid refractory aGVHD and cGVHD, with around 30 products in the pipeline targeting such populations. Therefore, such R&D activities are expected to contribute to growth of the graft versus host disease market over the forecast period.

Lack of regulatory guidelines is expected to hinder the market growth

The orphan nature of Gvhd has led to lack of guidelines and treatment regimes, which adversely impacts the market growth. Moreover, lack of randomized clinical trials for the treatment of Gvhd has resulted in inappropriate clinical evidences, which are not comparable and not directly applicable to all Gvhd patient groups. However, increasing focus on early detection of symptoms is expected to contribute to growth of the graft versus host disease market in the near future.

Increasing focus of major universities and institutes in R&D to further enhance the outcomes of Gvhd therapies is expected to propel the market growth. For instance, 2017, a research conducted by the University Of Michigan revised the understanding regarding the graft vs. host disease origins, which can offer new direction for potential therapies in the near future.

Key players in the market are focused on adopting inorganic growth strategies to expand their product portfolio

The global graft versus host disease market is competitive and fragmented. Major players in the market are focused on high investment in R&D and on adopting acquisition and collaboration strategies to enhance their market share. For instance, Kalytera Therapeutics, Inc. acquired Talent Biotechs Ltd. – an Israeli-based developer of proprietary cannabidiol therapeutic.

Major players operating in the Gvhd market include, Sanofi, Novartis AG, Neovii Biotech GmbH, Merck & Co., Astellas Pharma Inc., Soligenix, Inc., and Mesoblast Ltd.

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Key Developments

- Major companies are focused on various growth strategies such as gaining product approval from regulatory authorities, in order to expand their product portfolio. For instance, in May 2019, Incyte Corporation, a U.S.-based biopharmaceutical company, received the U.S. Food and Drug Administration (FDA) approval for 'Jakafi', a drug indicated for the treatment of steroid-refractory acute GVHD for adults and pediatric patients aged 12 years and above.

- Key players in the market are focused in various business strategies such as gaining product approval from regulatory authorities, in order to gain competitive edge in the market. For instance, in November 2017, Merck & Co., Inc., a pharmaceutical company, received the U.S. FDA approval for PREVYMIS, which is a tablet for oral use and injection for infusion. PREVYMIS is indicated for the patients suffering from GVHD.

- Key players in the market are focused in various business strategies such as gaining product approval from regulatory authorities, in order to gain competitive edge in the market. For instance, in August 2017, Pharmacyclics LLC, a biopharmaceutical company, received the U.S. FDA approval for Imbruvica (ibrutinib) drug, which will be used for adult patients with chronic graft versus host disease.

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