London, UK -- (SBWire) -- 10/18/2022 --The latest publication titled Companion Diagnostics – Thematic Research has been added to GlobalData Plc report store. Companion diagnostics (CDx) are molecular assays that measure levels of proteins, genes, or specific mutations to reveal a specific, efficacious therapy for an individual's condition. CDx are a form of personalized, stratified, and precision medicine due to which a patient's treatment will become increasingly individualized.

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CDx has expanded from a handful of oncology drugs with corresponding diagnostics to include multiple therapeutic areas, and the number of combinations has grown significantly over the years. However, oncology remains the largest segment for FDA-defined marketed drugs with CDx. The CDx thematic research report looks at the CDx medical devices market and some of the oncology biomarkers, indications, and diagnostic technologies being utilized. The market for biomarker testing continues to increase due to increases in disease, awareness, improved accessibility to personalized medicine, and technological advancements.2

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Companion Diagnostics Trends

Technology trends
- Big data
- AI
- Biomarker testing
- Laboratory developed tests
- Next-generation sequencing
- Liquid biopsies

Macroeconomic trends
- Decreasing cost of genetic testing
- The collaboration between diagnostic and pharmaceutical companies

Regulatory trends
- Impact of clinical guidelines

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Companion Diagnostics Value Chain Insights

The companion diagnostics value chain components comprise of following parameters:
Indications
- Breast cancer
- Colorectal cancer
- Leukemia
- Lung cancer
- Melanoma
- Ovarian cancer

Biomarkers
- BRCA
- HER2
- BRAF
- BCR-ABL
- ALK

Diagnostic technologies
- Immunohistochemistry tests
- In situ hybridization tests
- Nucleic acid amplification tests
- Sanger sequencing tests
- Next generation sequencing tests

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Companion Diagnostic Companies

GlobalData highlights publicly listed and private companies that are making their mark within the CDx theme.
- Abbott Laboratories: The company offers a broad range of diagnostics for hospitals, labs, blood banks, and clinics to diagnose and monitor health conditions. It also offers molecular diagnostic solutions by providing select appropriate therapies and monitor disease progression by analyzing DNA, RNA, and proteins at the molecular level. It is a leader in ALK and BCR-ABL tests, leading in ISH tests.
- Agilent Technologies: Agilent Technologies is a provider of instruments, reagents, software, services, and consumables for comprehensive laboratory workflow. Its product portfolio comprises liquid chromatography systems and components, gas chromatography systems and components, microarray solutions, clinical and diagnostic testing, and automation systems, among others. It is one of the leaders in BRCA tests and HER2 IHC tests.
- bioMerieux: bioMerieux, a subsidiary of Institut Merieux SA, develops, manufactures, and markets in vitro diagnostic solutions for hospitals and private laboratories. The company offers diagnostic solutions such as systems, reagents, and software for the diagnosis of infectious diseases, cardiovascular diseases, and cancers. It is one of the leaders in BRAF tests (NAAT).
- Illumina: Illumina provides genomic sequencing and array-based solutions for genetic analysis in the areas of molecular diagnostics, translational and consumer genomics, and cancer. The company's portfolio encompasses sequencing kits and reagents, sequencing tools and systems, microarray kits and reagents, molecular biology reagents, and arrays and reagents. It offers human whole-genome sequencing, microarray services, instrument services, training, and consulting. It leads in NGS testing.
- Thermo Fisher Scientific: Thermo Fisher Scientific is a provider of medical equipment, analytical instruments, reagents and consumables, software, and services to tackle complex analytical challenges in research, diagnostics, and clinical laboratories. It offers solutions for cellular analysis and biology, flow cytometry, and synthetic biology. The company has a range of products including technologies for mass spectrometry, genetic sequencing, electron microscopy, and protein and molecular biology research. It is one of the leaders in BRCA tests, ALK NGS tests, and Sanger sequencing.
- Asuragen
- Foundation Medicine
- MilliporeSigma
- Roche Diagnostics International

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