Lifestyle drugs have been a much debated segment of therapeutics for the pharmaceutical industry primarily due to the issues surrounding their inclusion in drug payment plans and diversion of resources for their research.

Dallas, TX -- (SBWire) -- 04/20/2010 -- ReportsandReports announce it will carry The Lifestyle Disorders Market Outlook to 2014: Reimbursement issues, market dynamics, pipeline compounds Market Research Report in its Store.

Lifestyle drugs have been a much debated segment of therapeutics for the pharmaceutical industry primarily due to the issues surrounding their inclusion in drug payment plans and diversion of resources for their research. These drugs have been a point of contention also because of a lack of clarity in defining them. For the purpose of this report, lifestyle diseases have been defined to include a range of indications that affect an individual’s quality of life even though they may not be deemed a medical problem.

The market was led by the MDD therapeutic segment followed by hormonal contraceptives. The smallest indication among the lifestyle disorders was alcohol dependence. The overall market was $37.2bn but is forecast to decline, albeit with a low single digit CAGR over the 2008-14 period.

Lifestyle disorders are marked by slowed R&D process and limited investigational products though MDD reflects some differences to this scenario. Each of the therapeutic indication s considered in this report reflects a markedly different scenario that substantiates the investment case around them. For instance:

- In the antidepressants market , the older antidepressants such as tricyclic s and monoamine oxidase inhibitors, have given way to agents that target metabolism, storage and release neurotransmitters such as serotonin and norepinephrine.
- In case of obesity, compounds with novel mechanisms of action such as GLP-1 pathway, monoamine transmission, PTP-1B receptor and melanin system, are being investigated.
- The hormonal contraceptives market is marked with little R&D that has led to gaps in contraceptive technology. The industry needs to invest in contraceptives with better side-effects profile to aid compliance.
- Growth of the erectile dysfunction market would be determined by the market dynamics ensuing between Viagra, Cialis and Levitra.
- In the smoking cessation market, growth prospects of the leading brands such as Pfizer’s Chantix, are likely to be determined by the market’s response to the black box label warnings on neuropsychiatric effects, introduced in July 2009.

Key features of this report
- Epidemiological analysis of the therapeutic segments and forecast prevalence over the period 2008-14
- Forecasts and analysis of the key products in the lifestyle disorders market over the period 2008-14, across major classes of treatments
- Overview of key events in the global lifestyle disorders market that have impacted treatment trends and sales potential.
- Strategic and growth analysis of leading pharmaceutical corporations based on sales focus by drug class, currently marketed products and R&D product portfolios
- Detailed analysis of the major classes of treatments across all the therapeutic segments analyzed in the report
- Detailed analysis of the clinically differentiated products in the lifestyle disorders market pipeline and sales forecast of key R&D pipeline products in the global lifestyle disorders market

Scope of this report
- Develop insights into patient potential with the report’s coverage of the therapy area and leading lifestyle disorders players today.
- Quickly understand how recent events are affecting the performance of major products and how leading players are confronting competitive challenges in the lifestyle disorders marketplace.
- Gain up-to-date market intelligence across the lifestyle disorders category and understand the major issues affecting key pharmaceutical marketers.
- Understand which drug classes have the greatest potential to drive lifestyle disorders franchise growth, and how pharmaceutical companies are attempting to capitalize these market opportunities.
- Compare the franchises of leading pharmaceutical marketers across key therapeutic classes and understand how market share of leading companies will evolve over the next six years.

Key Market Issues
- Reimbursement of lifestyle drugs replete with challenges
The reimbursement of lifestyle drugs is a much debated subject in most nations. This is primarily because most lifestyle disorders tend to be non-life threatening. One of the key drugs that brought into light the issues around reimbursement of lifestyle drugs has been Viagra, launched in 1998. Viagra’s launch raised concerns among governments and insurers about the budgetary implications of its reimbursement.
- The global contraceptives market – slowed R&D
Use of contraceptives has increased across different categories of women population and across geographies as well. However there is still need for further market penetration of contraceptives. The key concerns that women tend to have are the actual and perceived side effects of their use. From the industry front, there is little R&D in this therapeutic category that has led to gaps in contraceptive technology.
- CNS side-effects limiting the growth of smoking cessation products
Sanofi-Aventis terminated the development of its smoking cessation product Dianicline citing reasons that it was not differentiated adequately from Chantix. As the drug has the same mechanism of action as Chantix, the likely CNS side-effects made it less attractive. In July 2009, the FDA had added black box label warning on neuropsychiatric effects on Chantix and Zyban labels, which is likely to impede their growth over the forecast period.

Key findings from this report
- The R&D pipeline for lifestyle disorders shows a lot of variation across indications. For conditions such as MDD, there are several compounds under different investigational stages (both early and late) while indications such as alopecia reflect slowed R&D process.
- The antidepressants market R&D has been evolving and newer therapies have been emerging. The older antidepressants gave way to agents that target metabolism, storage and release of neurotransmitters such as serotonin and norepinephrine. The newer antidepressants such as SSRIs and SNRIs have a much better safety and side effects profile and have taken precedence in the less severe depression market.
- The global contraceptives market presents opportunities for companies to invest in considering the little R&D in this therapeutic category that has led to gaps in contraceptive technology. There is much scope for the industry to invest in contraceptives with better side-effects profile to aid compliance.
- Three closely-watched obesity drugs are currently under development - Arena Pharmaceuticals’ lorcaserin, Vivus’ Qnexa and Orexigen Therapeutics ‘Contrave . With few drug options in the obesity market, any approval would mark the first new obesity drug to enter the market in ten years.

Key questions answered
- Which companies were the leading players in the lifestyle disorders therapy area in 2008?
- How have recent major launches from the key market players performed?
- Which companies will become the key players in the lifestyle disorders market over the period 2008-14?
- Which products will be impacted by generic competitors over the period 2008-14?
- Which pipeline products are expected to generate sustainable revenue growth?

Table of Contents
The Lifestyle Disorders Market Outlook to 2014
Executive Summary 10
Lifestyle diseases – an overview 10
Global market analysis 11
Key investigational compounds 12
Competitive landscape 13
Scope and methodology 14
Scope 14
Methodology 14

Chapter 1 Lifestyle diseases – an overview 18
Summary 18
Introduction 19
Defining lifestyle diseases 20
Alcohol dependence 22
Chronic effects 22
Alopecia 23
Classification of Alopecia 23
Major depressive disorder (MDD) 24
Obesity 26
Causes of obesity 26
Hormonal contraception 28
Erectile dysfunction 29
Smoking cessation 30
Quitting 31
Treatment 31
Characteristics of lifestyle drugs 32
Simple dosing regimen 32
Fast onset of action 33
Tolerable side effects 33
Epidemiology of lifestyle diseases 33
Reimbursement of lifestyle drugs 38
Reimbursement of Viagra in the US 38
Reimbursement of Viagra in the EU 39
Reimbursement of other lifestyle drugs – issues and challenges 41

Chapter 2 Global market analysis 44
Summary 44
Introduction 45
Key recent events 45
Swiss Competition Commission imposes penalty on leading players 45
Naltrexone not shown to be effective for substance abuse in schizophrenics 45
Xenical and Alli being assessed for risk of liver injury 46
The global contraceptives market still presents investment opportunities 46
Market analysis for leading lifestyle indications 47
Major depressive disorder (MDD) 48
Introduction 48
Analysis of drug classes 49
Leading treatment brands 51
Trends in generics usage 54
Hormonal contraception 54
Introduction 54
Analysis of drug classes 55
Leading treatment brands 56
Trends in generics usage 58
Erectile dysfunction 58
Introduction 58
Analysis of drug classes 59
Leading treatment brands 60
Trends in generics usage 61
Smoking cessation 62
Introduction 62
Analysis of drug classes 62
Leading treatment brands 64
Trends in generics usage 65
Obesity 66
Introduction 66
Analysis of drug classes 67
Leading treatment brands 68
Trends in generics usage 70
Alcohol dependence 70
Introduction 70
Analysis of drug classes 71
Leading treatment brands 72
Trends in generics usage 73
Alopecia 73
Introduction 73
Analysis of drug classes 74
Leading treatments 75
Lifestyle disorders sales forecast 76
Leading brands dynamics 77
Leading brands sales forecasts 79

Chapter 3 Key investigational compounds 82
Summary 82
Introduction 83
Key trends in R&D 83
Obesity – different mechanisms of action being explored 83
Campral the first new drug in alcohol dependence in two decades 83
Vivitrol potential being explored in opioid dependence 84
Antabuse – a novel mechanism of action but presents compliance issues 84
Evolving novel mechanisms of action in the MDD market 84
Sanofi-Aventis terminated development of smoking cessation product
Dianicline 85
Profiles of leading drugs in development 85
Compounds awaiting regulatory approval compounds 86
WC 3016 (Norethindrone/ethinyl estradiol) – Warner Chilcott 86
Qnexa (phentermine/topiramate) – Vivus 88
APD356 (lorcaserin) – Arena 89
Phase III compounds 91
Contrave (bupropion/naltrexone) – Orexigen 91
The increasingly competitive obesity environment 92
Vilazodone – Clinical Data 94
F2695 (levomilnacipran) – Pierre Fabre/Forest 95
TA-1790 (avanafil) – Mitsubishi Tanabe/Vivus 96
NicVAX – Nabi Biopharmaceuticals/GSK 97
NIC002 (CYT002-NicQb) – Novartis/Cytos 99
Naltrexone depot – Elbion AG 100
Key investigational compounds sales forecast 101

Chapter 4 Competitive landscape 104
Summary 104
Introduction 105
Wyeth 108
Overview 108
Drug class focus 108
Marketed products portfolio 109
R&D pipeline analysis 110
Strategic growth analysis 110
Drivers of growth 110
Resistors to growth 111
Eli Lilly 111
Overview 111
Drug class focus 112
Marketed products portfolio 113
R&D pipeline analysis 114
Strategic growth analysis 114
Drivers of growth 114
Resistors to growth 115
Pfizer 115
Overview 115
Drug class focus 115
Marketed products portfolio 116
R&D pipeline analysis 118
Strategic growth analysis 118
Drivers of growth 118
Resistors to growth 118
Bayer 119
Overview 119
Drug class focus 119
Marketed products portfolio 120
R&D pipeline analysis 121
Strategic growth analysis 121
Drivers of growth 121
Resistors to growth 122
Forest 122
Overview 122
Drug class focus 122
Marketed products portfolio 123
R&D pipeline analysis 124
Strategic growth analysis 125
Drivers of growth 125
Resistors to growth 125
Dynamics of the leading alopecia market players 126
The competitive positioning of leading generic players 127

Chapter 5 Appendix 128
IMS data 128
Glossary 129
Index 131

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